Ki Summary

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Target

Cyclin-T1

Ligand

BDBM126537

Substrate/Competitor

n/a

Meas. Tech.

IMAP Assay

IC50

0.002±n/a nM

Citation

Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent US8778951 Publication Date 7/15/2014

More Info.:

Get all data from this article, Assay Method

Cyclin-T1

Name:

Cyclin-T1

Synonyms:

Type:

Enzyme Subunit

Mol. Mass.:

80712.40

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

726

Sequence:

MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTIN
TAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPD
TRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATN
SLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHE
FLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLM
SMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV
DHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAY
AAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEI
KMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNK
RPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSL
NFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDT
VNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPP
LPPLPK

BDBM126537

n/a

Name

BDBM126537

Synonyms:

US8778951, 348

Type

Small organic molecule

Emp. Form.

C27H37Cl2N5O3S

Mol. Mass.

582.585

SMILES

Clc1ccc(NCC2CCOCC2)nc1-c1cc(NC2CCC(CC2)NC2CCS(=O)(=O)CC2)ncc1Cl |(-8,.23,;-6.67,-.54,;-6.67,-2.08,;-5.33,-2.85,;-4,-2.08,;-2.67,-2.85,;-1.33,-2.08,;,-2.85,;,-4.39,;1.33,-5.16,;2.67,-4.39,;2.67,-2.85,;1.33,-2.08,;-4,-.54,;-5.33,.23,;-5.33,1.77,;-4,2.54,;-4,4.08,;-2.67,4.85,;-1.33,4.08,;-1.33,2.54,;,1.77,;1.33,2.54,;1.33,4.08,;,4.85,;2.67,1.77,;4,2.54,;5.33,1.77,;6.67,2.54,;6.67,4.08,;7.76,5.16,;8,3.31,;5.33,4.85,;4,4.08,;-5.33,4.85,;-6.67,4.08,;-6.67,2.54,;-8,1.77,)|

Structure