Ki Summary

Reaction Details

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Target

Cyclin-T1

Ligand

BDBM126549

Substrate/Competitor

n/a

Meas. Tech.

IMAP Assay

IC50

0.00028±n/a nM

Citation

Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent US8778951 Publication Date 7/15/2014

More Info.:

Get all data from this article, Assay Method

Cyclin-T1

Name:

Cyclin-T1

Synonyms:

Type:

Enzyme Subunit

Mol. Mass.:

80712.40

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

726

Sequence:

MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTIN
TAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPD
TRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATN
SLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHE
FLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLM
SMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV
DHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAY
AAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEI
KMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNK
RPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSL
NFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDT
VNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPP
LPPLPK

BDBM126549

n/a

Name

BDBM126549

Synonyms:

US8778951, 360

Type

Small organic molecule

Emp. Form.

C25H33ClN6O

Mol. Mass.

469.022

SMILES

CCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 |r,wU:6.9,wD:3.2,(6.67,1.93,;5.33,2.7,;4,1.93,;2.67,2.7,;2.67,4.24,;1.33,5,;,4.24,;,2.7,;1.33,1.93,;-1.33,5.01,;-2.67,4.23,;-2.67,2.69,;-4,1.92,;-5.33,2.69,;-6.67,1.92,;-5.33,4.23,;-4,5,;-4,.38,;-5.33,-.39,;-5.33,-1.93,;-4,-2.7,;-2.67,-1.93,;-1.33,-2.7,;,-1.93,;1.33,-2.7,;1.33,-4.24,;2.67,-5.01,;4,-4.24,;4,-2.7,;2.67,-1.93,;1.33,-1.16,;1.33,.38,;-2.67,-.39,)|

Structure