Ki Summary

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Target

Cyclin-T1

Ligand

BDBM126552

Substrate/Competitor

n/a

Meas. Tech.

IMAP Assay

IC50

0.00043±n/a nM

Citation

Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent US8778951 Publication Date 7/15/2014

More Info.:

Get all data from this article, Assay Method

Cyclin-T1

Name:

Cyclin-T1

Synonyms:

Type:

Enzyme Subunit

Mol. Mass.:

80712.40

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

726

Sequence:

MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTIN
TAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPD
TRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATN
SLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHE
FLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLM
SMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV
DHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAY
AAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEI
KMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNK
RPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSL
NFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDT
VNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPP
LPPLPK

BDBM126552

n/a

Name

BDBM126552

Synonyms:

US8778951, 363

Type

Small organic molecule

Emp. Form.

C28H37ClN6O2

Mol. Mass.

525.085

SMILES

Clc1cnc(N[C@H]2CC[C@@H](CC2)NC2CCOCC2)cc1-c1cccc(NCC2(CCOCC2)C#N)n1 |r,wU:6.5,wD:9.12,(-7.57,1.92,;-6.23,2.69,;-6.23,4.23,;-4.9,5,;-3.56,4.23,;-2.23,5.01,;-.9,4.24,;.44,5.01,;1.77,4.24,;1.77,2.7,;.44,1.93,;-.9,2.7,;3.1,1.93,;4.59,2.32,;5.68,1.23,;7.17,1.63,;7.57,3.12,;6.48,4.21,;4.99,3.81,;-3.56,2.69,;-4.9,1.92,;-4.9,.38,;-6.23,-.39,;-6.23,-1.93,;-4.9,-2.7,;-3.56,-1.93,;-2.23,-2.7,;-.9,-1.93,;.44,-2.7,;.44,-4.24,;1.77,-5.01,;3.1,-4.24,;3.1,-2.7,;1.77,-1.93,;.44,-1.16,;.44,.38,;-3.56,-.39,)|

Structure