Ki Summary

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Target

Cyclin-T1

Ligand

BDBM126554

Substrate/Competitor

n/a

Meas. Tech.

IMAP Assay

IC50

0.0007±n/a nM

Citation

Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent US8778951 Publication Date 7/15/2014

More Info.:

Get all data from this article, Assay Method

Cyclin-T1

Name:

Cyclin-T1

Synonyms:

Type:

Enzyme Subunit

Mol. Mass.:

80712.40

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

726

Sequence:

MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTIN
TAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPD
TRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATN
SLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHE
FLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLM
SMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV
DHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAY
AAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEI
KMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNK
RPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSL
NFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDT
VNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPP
LPPLPK

BDBM126554

n/a

Name

BDBM126554

Synonyms:

US8778951, 365

Type

Small organic molecule

Emp. Form.

C27H40ClN5O3S

Mol. Mass.

550.156

SMILES

COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(C)CCS(=O)(=O)CC2)n1 |r,wU:9.12,wD:6.5,3.3,(8,3.36,;6.67,4.13,;5.33,3.36,;4,4.13,;4,5.67,;2.67,3.36,;1.33,4.13,;1.33,5.67,;,6.44,;-1.33,5.67,;-1.33,4.13,;,3.36,;-2.67,6.44,;-4,5.67,;-4,4.13,;-5.33,3.36,;-6.67,4.13,;-8,3.36,;-6.67,5.67,;-5.33,6.44,;-5.33,1.82,;-6.67,1.05,;-6.67,-.49,;-5.33,-1.26,;-4,-.49,;-2.67,-1.26,;-2.67,-2.8,;-1.33,-3.57,;-1.33,-2.03,;-1.33,-5.11,;,-5.88,;1.33,-5.11,;2.87,-5.11,;2.1,-6.44,;1.33,-3.57,;,-2.8,;-4,1.05,)|

Structure