Reaction Details | |||
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Target | Serine/threonine-protein kinase mTOR | ||
Ligand | BDBM127403 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biochemical Assay | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
Ki | 0.204±n/a nM | ||
Comments | extracted | ||
Citation | Cheng, H; Johnson, TW; Hoffman, JE; Guo, LC; Liu, Z Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions US Patent US8791131 Publication Date 7/29/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase mTOR | |||
Name: | Serine/threonine-protein kinase mTOR | ||
Synonyms: | FK506-binding protein 12-rapamycin complex-associated protein 1 | FKBP12-rapamycin complex-associated protein | FRAP | FRAP 1 (mTOR) | FRAP1 | FRAP2 | MTOR | MTOR_HUMAN | Mammalian Target of Rapamycin (mTOR) | P42345 | RAFT1 | RAPT1 | Rapamycin and FKBP12 target 1 | Rapamycin target protein | Serine/threonine-protein kinase (mTOR) | mTORC2 | ||
Type: | Rapamycin target protein | ||
Mol. Mass.: | 288917.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P42345 | ||
Residue: | 2549 | ||
Sequence: |
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BDBM127403 | |||
n/a | |||
Name | BDBM127403 | ||
Synonyms: | US8791131, 168 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H20N6O2 | ||
Mol. Mass. | 364.4011 | ||
SMILES | Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1cn[nH]c1 |r,wU:13.14,wD:16.18,(5.84,-1.53,;4.35,-1.13,;3.2,-2.16,;3.2,-3.7,;1.87,-4.47,;.54,-3.7,;-.8,-4.47,;-2.13,-3.7,;-2.13,-2.16,;-.8,-1.39,;.54,-2.16,;1.87,-1.39,;2.19,.12,;1.1,1.2,;-.39,.81,;-1.48,1.89,;-1.08,3.38,;-2.17,4.47,;.41,3.78,;1.5,2.69,;3.72,.28,;4.49,1.61,;-3.47,-1.39,;-4.93,-1.87,;-5.84,-.62,;-4.93,.62,;-3.47,.15,)| | ||
Structure |