Reaction Details | |||
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Target | Fatty acid synthase | ||
Ligand | BDBM128365 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biological Assay | ||
pH | 7±n/a | ||
IC50 | 40±n/a nM | ||
Comments | extracted | ||
Citation | Adams, ND; Aquino, CJ; Chaudhari, AM; Ghergurovich, JM; Kiesow, TJ; Parrish, CA; Reif, AJ; Wiggall, K Triazolones as fatty acid synthase inhibitors US Patent US8802864 Publication Date 8/12/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
Fatty acid synthase | |||
Name: | Fatty acid synthase | ||
Synonyms: | FAS | FASN | FAS_HUMAN | Fatty acid synthase (FASN) | HU FASN | ||
Type: | Enzyme | ||
Mol. Mass.: | 273419.37 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P49327 | ||
Residue: | 2511 | ||
Sequence: |
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BDBM128365 | |||
n/a | |||
Name | BDBM128365 | ||
Synonyms: | US8802864, 116 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H25FN4O3 | ||
Mol. Mass. | 436.4787 | ||
SMILES | COc1ccc(cc1)-c1ccc(c(F)c1)-n1c(C[C@@H]2CCN(C2)C(=O)C2CC2)n[nH]c1=O |r,wU:18.19,(6.96,-3.59,;6.19,-2.25,;4.65,-2.25,;3.88,-3.59,;2.34,-3.59,;1.57,-2.25,;2.34,-.92,;3.88,-.92,;.03,-2.25,;-.74,-.92,;-2.28,-.92,;-3.05,-2.25,;-2.28,-3.59,;-3.05,-4.92,;-.74,-3.59,;-4.59,-2.25,;-5.5,-1.01,;-5.1,.48,;-3.61,.88,;-2.36,-.03,;-1.12,.88,;-1.59,2.34,;-3.13,2.34,;-.5,3.43,;-.9,4.92,;.98,3.03,;2.07,1.95,;2.47,3.43,;-6.96,-1.48,;-6.96,-3.02,;-5.5,-3.5,;-4.73,-4.83,)| | ||
Structure |