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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fatty acid synthase | ||
| Ligand | BDBM128367 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biological Assay | ||
| pH | 7±n/a | ||
| IC50 | 398±n/a nM | ||
| Comments | extracted | ||
| Citation |  Adams, ND; Aquino, CJ; Chaudhari, AM; Ghergurovich, JM; Kiesow, TJ; Parrish, CA; Reif, AJ; Wiggall, K Triazolones as fatty acid synthase inhibitors US Patent US8802864 Publication Date 8/12/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fatty acid synthase | |||
| Name: | Fatty acid synthase | ||
| Synonyms: | FAS | FASN | FAS_HUMAN | Fatty acid synthase (FASN) | HU FASN | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 273419.37 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P49327 | ||
| Residue: | 2511 | ||
| Sequence: |
| ||
| BDBM128367 | |||
| n/a | |||
| Name | BDBM128367 | ||
| Synonyms: | US8802864, 158 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H26FN5O3 | ||
| Mol. Mass. | 463.504 | ||
| SMILES | CC(=O)Nc1ccc(cc1)-c1ccc(c(F)c1)-n1c(C[C@@H]2CCN(C2)C(=O)C2CC2)n[nH]c1=O |r,wU:20.21,(7.73,-3.74,;6.19,-3.74,;5.42,-5.07,;5.42,-2.41,;3.88,-2.41,;3.11,-3.74,;1.57,-3.74,;.8,-2.41,;1.57,-1.07,;3.11,-1.07,;-.74,-2.41,;-1.51,-1.07,;-3.05,-1.07,;-3.82,-2.41,;-3.05,-3.74,;-3.82,-5.07,;-1.51,-3.74,;-5.36,-2.41,;-6.27,-1.16,;-5.5,.17,;-4.16,.94,;-2.92,.04,;-1.67,.94,;-2.15,2.41,;-3.69,2.41,;-1.38,3.74,;-2.15,5.07,;.16,3.74,;1.5,2.97,;1.5,4.51,;-7.73,-1.64,;-7.73,-3.18,;-6.27,-3.65,;-5.5,-4.99,)| | ||
| Structure | 
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