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TargetFibroblast growth factor receptor 3
LigandBDBM128624
Substrate/Competitorn/a
Meas. Tech.In Vitro Kinase Inhibition Assay
pH8±n/a
Temperature298.15±n/a K
IC50 0.46±n/a nM
Commentsextracted
Citation Berdini, VCarr, MGCongreve, MSFrederickson, MGriffiths-Jones, CMHamlett, CCMadin, AMurray, CWBenning, RKSaxty, GVickerstaffe, EWilliams, BJWoodhead, AJWoodhead, SJFreyne, EJGovaerts, TCAngibaud, PR Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases US Patent US8796244 Publication Date 8/5/2014
More Info.:Get all data from this article,  Assay Method
 
Fibroblast growth factor receptor 3
Name:Fibroblast growth factor receptor 3
Synonyms:CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:Protein
Mol. Mass.:87699.57
Organism:Homo sapiens (Human)
Description:P22607
Residue:806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE
EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK
RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE
GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN
LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ
VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW
MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT
HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS
SSSGDDSVFAHDLLPPAPPSSGGSRT
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BDBM128624
n/a
NameBDBM128624
Synonyms:US8796244, 213
TypeSmall organic molecule
Emp. Form.C23H17F3N8O
Mol. Mass.478.4293
SMILESFC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1nccc(n1)-n1ccnc1
Structure
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