| Reaction Details |
|---|
 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase Mdm2 |
|---|
| Ligand | BDBM129796 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay |
|---|
| IC50 | 0.07±n/a nM |
|---|
| Citation |  Furet, P; Guagnano, V; Holzer, P; Kallen, J; Liao, L; Mah, R; Mao, L; Masuya, K; Schlapbach, A; Stutz, S; Vaupel, A Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases US Patent US8815926 Publication Date 8/26/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| E3 ubiquitin-protein ligase Mdm2 |
|---|
| Name: | E3 ubiquitin-protein ligase Mdm2 |
|---|
| Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
|---|
| Type: | Oncoprotein |
|---|
| Mol. Mass.: | 55196.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q00987 |
|---|
| Residue: | 491 |
|---|
| Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
|
|
|
|---|
| BDBM129796 |
|---|
| n/a |
|---|
| Name | BDBM129796 |
|---|
| Synonyms: | US8815926, 75 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H27Cl2N5O3 |
|---|
| Mol. Mass. | 552.452 |
|---|
| SMILES | COc1ncc(-c2nc3C(=O)N([C@H](c3n2C(C)C)c2ccc(Cl)cc2C)c2cc(Cl)ccc2C)c(OC)n1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
