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TargetFibroblast growth factor receptor 3
LigandBDBM102548
Substrate/Competitorn/a
Meas. Tech.LanthaScreen TR-FRET Assay
Temperature298.15±n/a K
IC50 16±n/a nM
Commentsextracted
Citation Furet, PGraus Porta, DGuagnano, V Quinoline carboxamide derivatives as protein tyrosine kinase inhibitors US Patent US8815901 Publication Date 8/26/2014
More Info.:Get all data from this article,  Assay Method
 
Fibroblast growth factor receptor 3
Name:Fibroblast growth factor receptor 3
Synonyms:CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:Protein
Mol. Mass.:87699.57
Organism:Homo sapiens (Human)
Description:P22607
Residue:806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE
EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK
RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE
GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN
LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ
VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW
MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT
HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS
SSSGDDSVFAHDLLPPAPPSSGGSRT
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  Blast E-value cutoff:
BDBM102548
n/a
NameBDBM102548
Synonyms:US8536175, 174
TypeSmall organic molecule
Emp. Form.C29H29F2N5O3
Mol. Mass.533.5691
SMILESCOc1cc(OC)c(F)c(c1F)-c1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cn2)c2ncccc12 |(10.39,-2.67,;8.85,-2.67,;8.08,-1.34,;8.85,-.01,;8.08,1.33,;8.85,2.66,;8.08,3.99,;6.54,1.33,;5.77,2.66,;5.77,-.01,;6.54,-1.34,;5.77,-2.67,;4.23,-.01,;3.46,1.33,;1.92,1.33,;1.15,-.01,;-.39,-.01,;-1.16,1.33,;-1.16,-1.34,;-2.7,-1.34,;-3.47,-.01,;-5.01,-.01,;-5.78,-1.34,;-7.32,-1.34,;-8.09,-.01,;-7.32,1.33,;-8.09,2.66,;-9.63,2.66,;-10.4,3.99,;-10.4,1.33,;-9.63,-.01,;-5.01,-2.67,;-3.47,-2.67,;1.92,-1.34,;1.15,-2.67,;1.92,-4.01,;3.46,-4.01,;4.23,-2.67,;3.46,-1.34,)|
Structure
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