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TargetMembrane metallo-endopeptidase-like 1
LigandBDBM130362
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 0.7±n/a nM
Commentsextracted
Citation Iwaki, YKarki, RGKsander, GM Substituted aminopropionic derivatives as neprilysin inhibitors US Patent US8822534 Publication Date 9/2/2014
More Info.:Get all data from this article,  Assay Method
 
Membrane metallo-endopeptidase-like 1
Name:Membrane metallo-endopeptidase-like 1
Synonyms:Endopeptidase (NEP) | MELL1 | MMEL1 | MMEL1_HUMAN | MMEL2 | NEP2 | Neutral endopeptidase (NEP)
Type:Enzyme
Mol. Mass.:89358.76
Organism:Homo sapiens (Human)
Description:Q495T6
Residue:779
Sequence:
MGKSEGPVGMVESAGRAGQKRPGFLEGGLLLLLLLVTAALVALGVLYADRRGKQLPRLAS
RLCFLQEERTFVKRKPRGIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFAC
GGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSV
IEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWND
DQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCL
VQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLS
SVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRV
NYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFV
ETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENS
LQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQ
ALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSW
DLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYA
QVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM130362
n/a
NameBDBM130362
Synonyms:US8822534, Example 5-55 | US8993631, 5-11
TypeSmall organic molecule
Emp. Form.C21H19FN2O6
Mol. Mass.414.3838
SMILESCOc1ccc(F)cc1-c1ccc(C[C@H](CC(O)=O)NC(=O)c2cc(O)no2)cc1
Structure
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