| Reaction Details |
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 | Report a problem with these data |
| Target | Membrane metallo-endopeptidase-like 1 |
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| Ligand | BDBM130365 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 1.1±n/a nM |
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| Comments | extracted |
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| Citation |  Iwaki, Y; Karki, RG; Ksander, GM Substituted aminopropionic derivatives as neprilysin inhibitors US Patent US8822534 Publication Date 9/2/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Membrane metallo-endopeptidase-like 1 |
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| Name: | Membrane metallo-endopeptidase-like 1 |
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| Synonyms: | Endopeptidase (NEP) | MELL1 | MMEL1 | MMEL1_HUMAN | MMEL2 | NEP2 | Neutral endopeptidase (NEP) |
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| Type: | Enzyme |
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| Mol. Mass.: | 89358.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q495T6 |
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| Residue: | 779 |
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| Sequence: | MGKSEGPVGMVESAGRAGQKRPGFLEGGLLLLLLLVTAALVALGVLYADRRGKQLPRLAS
RLCFLQEERTFVKRKPRGIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFAC
GGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSV
IEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWND
DQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCL
VQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLS
SVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRV
NYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFV
ETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENS
LQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQ
ALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSW
DLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYA
QVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW
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| BDBM130365 |
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| n/a |
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| Name | BDBM130365 |
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| Synonyms: | US8822534, Example 11-1 | US8822534, Example 12-1 | US8993631, 9-1 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20ClNO5 |
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| Mol. Mass. | 389.83 |
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| SMILES | OC(=O)CCC(=O)N[C@@H](CC(O)=O)Cc1ccc(cc1)-c1cccc(Cl)c1 |
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| Structure | 
|
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