| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Membrane metallo-endopeptidase-like 1 |
|---|
| Ligand | BDBM130367 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 0.07±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Iwaki, Y; Karki, RG; Ksander, GM Substituted aminopropionic derivatives as neprilysin inhibitors US Patent US8822534 Publication Date 9/2/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Membrane metallo-endopeptidase-like 1 |
|---|
| Name: | Membrane metallo-endopeptidase-like 1 |
|---|
| Synonyms: | Endopeptidase (NEP) | MELL1 | MMEL1 | MMEL1_HUMAN | MMEL2 | NEP2 | Neutral endopeptidase (NEP) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 89358.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q495T6 |
|---|
| Residue: | 779 |
|---|
| Sequence: | MGKSEGPVGMVESAGRAGQKRPGFLEGGLLLLLLLVTAALVALGVLYADRRGKQLPRLAS
RLCFLQEERTFVKRKPRGIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFAC
GGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSV
IEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWND
DQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCL
VQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLS
SVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRV
NYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFV
ETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENS
LQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQ
ALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSW
DLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYA
QVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW
|
|
|
|---|
| BDBM130367 |
|---|
| n/a |
|---|
| Name | BDBM130367 |
|---|
| Synonyms: | US8822534, Example 11-14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17ClN2O5 |
|---|
| Mol. Mass. | 400.812 |
|---|
| SMILES | OC(=O)C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(O)no1 |
|---|
| Structure | 
|
|---|
Search and Browse
