Reaction Details |
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Target | Membrane metallo-endopeptidase-like 1 |
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Ligand | BDBM130369 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 0.8±n/a nM |
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Comments | extracted |
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Citation | Iwaki, Y; Karki, RG; Ksander, GM Substituted aminopropionic derivatives as neprilysin inhibitors US Patent US8822534 Publication Date 9/2/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Membrane metallo-endopeptidase-like 1 |
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Name: | Membrane metallo-endopeptidase-like 1 |
Synonyms: | Endopeptidase (NEP) | MELL1 | MMEL1 | MMEL1_HUMAN | MMEL2 | NEP2 | Neutral endopeptidase (NEP) |
Type: | Enzyme |
Mol. Mass.: | 89358.76 |
Organism: | Homo sapiens (Human) |
Description: | Q495T6 |
Residue: | 779 |
Sequence: | MGKSEGPVGMVESAGRAGQKRPGFLEGGLLLLLLLVTAALVALGVLYADRRGKQLPRLAS
RLCFLQEERTFVKRKPRGIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFAC
GGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSV
IEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWND
DQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCL
VQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLS
SVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRV
NYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFV
ETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENS
LQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQ
ALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSW
DLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYA
QVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW
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BDBM130369 |
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n/a |
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Name | BDBM130369 |
Synonyms: | US8822534, Example 14-1 | US8993631, 11-1 |
Type | Small organic molecule |
Emp. Form. | C19H19ClN2O5 |
Mol. Mass. | 390.818 |
SMILES | OC(=O)CNC(=O)N[C@@H](CC(O)=O)Cc1ccc(cc1)-c1cccc(Cl)c1 |
Structure |
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