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TargetArginase (SmARG)
LigandBDBM130381
Substrate/Competitorn/a
Meas. Tech.ITC
pH8.5±0
Kd 5.4e+2± 8e+1 nM
Citation Hai YEdwards JEVan Zandt MCHoffmann KFChristianson DW Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis Biochemistry 53:4671-4684 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Arginase (SmARG)
Name:Arginase (SmARG)
Synonyms:n/a
Type:Protein
Mol. Mass.:39912.83
Organism:Schistosoma mansoni (flatworms)
Description:Q6WVP6
Residue:364
Sequence:
MLKSVATPYYPIQDEKPKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDG
IQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKHTVELSGSK
STPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVK
ELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEA
VIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKL
SVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHM
QTKQ
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  Blast E-value cutoff:
BDBM130381
n/a
NameBDBM130381
Synonyms:(R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)piperidin-4-yl]hexanoic acid (ABH-DP)
TypeSmall organic molecule
Emp. Form.C18H27BCl2N2O4
Mol. Mass.417.135
SMILESN[C@](CCCCB(O)O)(C1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)C(O)=O
Structure
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