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TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
LigandBDBM130498
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH7.5±n/a
IC50 38±n/a nM
Commentsextracted
Citation Hendrix, M; Bärfacker, L; Erb, C; Hafner, F; Heckroth, H; Karthaus, D; Tersteegen, A; van der Staay, F; van Kampen, M 6-cyclylmethyl-and 6-alkylmethyl-substituted pyrazolepyrimidines US Patent US8822479 Publication Date 9/2/2014
More Info.:Get all data from this article,  Assay Method
 
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Name:High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Synonyms:3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A)
Type:Protein
Mol. Mass.:68488.40
Organism:Homo sapiens (Human)
Description:O76083
Residue:593
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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  Blast E-value cutoff:
BDBM130498
n/a
NameBDBM130498
Synonyms:US8822479, 2
TypeSmall organic molecule
Emp. Form.C19H22N4O
Mol. Mass.322.4042
SMILESCc1cccc(c1C)-n1ncc2c1nc(CC1CCCC1)[nH]c2=O
Structure
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