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TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
LigandBDBM130729
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH8±n/a
IC50 1.7±n/a nM
Commentsextracted
Citation Kaizawa, HYamamoto, HKamijo, KSugita, MSeo, RYamamoto, SUkai, A Pyrazoloquinoline compound US Patent US8822448 Publication Date 9/2/2014
More Info.:Get all data from this article,  Assay Method
 
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Name:High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Synonyms:PDE9A_RAT | Pde9a | Phosphodiesterase 9 (PDE9)
Type:Enzyme
Mol. Mass.:61749.01
Organism:Rattus norvegicus (Rat)
Description:Q8QZV1
Residue:534
Sequence:
MGAGSSSYRPKAIYLDIDGRIQKVVFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAVKQVSEREELVQGVLAQVAEQFSRAFKINELKAEVANH
LAMLEKRVELEGLKVVEIEKCKSDIKKMREELAARNNRTNCPCKYSFLDNKKLTPRRDVP
TYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLC
VHDNYRSNPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNN
TYQINARTELAVRYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLIL
ATDMARHAEIMDSFKEKMENFDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLL
EEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPIVEETMLR
PLWESREHYEELKQLDDAMKELQKKTENLTSGATENAPEKTRDAKDNEDRSPPN
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BDBM130729
n/a
NameBDBM130729
Synonyms:US8822448, 94
TypeSmall organic molecule
Emp. Form.C24H28F2N4O4
Mol. Mass.474.5003
SMILESCc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCC(CC1)OCC(F)F
Structure
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