| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Ligand | BDBM130781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 8±n/a |
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| IC50 | 1.2±n/a nM |
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| Comments | extracted |
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| Citation |  Kaizawa, H; Yamamoto, H; Kamijo, K; Sugita, M; Seo, R; Yamamoto, S; Ukai, A Pyrazoloquinoline compound US Patent US8822448 Publication Date 9/2/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Synonyms: | PDE9A_RAT | Pde9a | Phosphodiesterase 9 (PDE9) |
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| Type: | Enzyme |
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| Mol. Mass.: | 61749.01 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q8QZV1 |
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| Residue: | 534 |
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| Sequence: | MGAGSSSYRPKAIYLDIDGRIQKVVFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAVKQVSEREELVQGVLAQVAEQFSRAFKINELKAEVANH
LAMLEKRVELEGLKVVEIEKCKSDIKKMREELAARNNRTNCPCKYSFLDNKKLTPRRDVP
TYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLC
VHDNYRSNPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNN
TYQINARTELAVRYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLIL
ATDMARHAEIMDSFKEKMENFDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLL
EEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPIVEETMLR
PLWESREHYEELKQLDDAMKELQKKTENLTSGATENAPEKTRDAKDNEDRSPPN
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| BDBM130781 |
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| n/a |
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| Name | BDBM130781 |
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| Synonyms: | US8822448, 211 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30F3N5O2 |
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| Mol. Mass. | 489.5332 |
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| SMILES | C[C@H]1CN(CCN1CCC(F)(F)F)C(=O)c1cc2c3n(CC4CCC4)ncc3c(=O)[nH]c2cc1C |r| |
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| Structure | 
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