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TargetDihydrofolate reductase
LigandBDBM131844
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 0.12±n/a nM
Citation Chen, ZCreighton, CJCunningham, MFinn, JHilgers, MJung, MKohnen, LALam, TLi, XStidham, MTari, LTrzoss, MZhang, J Dihydrofolate reductase inhibitors US Patent US8835445 Publication Date 9/16/2014
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_STAAU | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase (DfrB) | Tetrahydrofolate dehydrogenase | folA
Type:Enzyme
Mol. Mass.:18249.71
Organism:Staphylococcus aureus
Description:n/a
Residue:159
Sequence:
MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRN
VVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRG
DTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK
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BDBM131844
n/a
NameBDBM131844
Synonyms:US8835445, 20
TypeSmall organic molecule
Emp. Form.C20H20F2N6OS
Mol. Mass.430.474
SMILESCOc1ccc2nc(SCCC(C)(F)F)n(-c3ccc4c(N)nc(N)nc4c3)c2c1
Structure
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