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TargetDihydrofolate reductase
LigandBDBM131856
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 0.2±n/a nM
Citation Chen, ZCreighton, CJCunningham, MFinn, JHilgers, MJung, MKohnen, LALam, TLi, XStidham, MTari, LTrzoss, MZhang, J Dihydrofolate reductase inhibitors US Patent US8835445 Publication Date 9/16/2014
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_STAAU | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase (DfrB) | Tetrahydrofolate dehydrogenase | folA
Type:Enzyme
Mol. Mass.:18249.71
Organism:Staphylococcus aureus
Description:n/a
Residue:159
Sequence:
MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRN
VVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRG
DTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK
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BDBM131856
n/a
NameBDBM131856
Synonyms:US8835445, 39
TypeSmall organic molecule
Emp. Form.C21H22N6O2S
Mol. Mass.422.503
SMILESCc1c(nc(-c2cccs2)n1-c1ccc2c(N)nc(N)nc2c1)C(=O)OC(C)(C)C
Structure
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