Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM131856 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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Ki | 0.2±n/a nM |
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Citation | Chen, Z; Creighton, CJ; Cunningham, M; Finn, J; Hilgers, M; Jung, M; Kohnen, LA; Lam, T; Li, X; Stidham, M; Tari, L; Trzoss, M; Zhang, J Dihydrofolate reductase inhibitors US Patent US8835445 Publication Date 9/16/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_STAAU | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase (DfrB) | Tetrahydrofolate dehydrogenase | folA |
Type: | Enzyme |
Mol. Mass.: | 18249.71 |
Organism: | Staphylococcus aureus |
Description: | n/a |
Residue: | 159 |
Sequence: | MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRN
VVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRG
DTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK
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BDBM131856 |
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n/a |
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Name | BDBM131856 |
Synonyms: | US8835445, 39 |
Type | Small organic molecule |
Emp. Form. | C21H22N6O2S |
Mol. Mass. | 422.503 |
SMILES | Cc1c(nc(-c2cccs2)n1-c1ccc2c(N)nc(N)nc2c1)C(=O)OC(C)(C)C |
Structure |
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