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TargetDihydrofolate reductase
LigandBDBM50351173
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 0.025±n/a nM
Citation Chen, ZCreighton, CJCunningham, MFinn, JHilgers, MJung, MKohnen, LALam, TLi, XStidham, MTari, LTrzoss, MZhang, J Dihydrofolate reductase inhibitors US Patent US8835445 Publication Date 9/16/2014
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_STAAU | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase (DfrB) | Tetrahydrofolate dehydrogenase | folA
Type:Enzyme
Mol. Mass.:18249.71
Organism:Staphylococcus aureus
Description:n/a
Residue:159
Sequence:
MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRN
VVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRG
DTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK
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BDBM50351173
n/a
NameBDBM50351173
Synonyms:CHEMBL1818129 | US8835445, 40
TypeSmall organic molecule
Emp. Form.C22H27N5O2
Mol. Mass.393.4821
SMILESCCOc1ccc(cc1-c1cc2nc(N)nc(N)c2cc1C)C(=O)N(CC)CC
Structure
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