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TargetCyclin-dependent kinase 4
LigandBDBM132440
Substrate/Competitorn/a
Meas. Tech.In Vitro Assay
pH7.4±n/a
Temperature310.15±n/a K
IC50 2±n/a nM
Citation Connors RVKang DEksterowicz JFan PFisher BFu JLi KLi ZMcGee LRSharma RWang XMcMinn DLMihalic JTDeignan J Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors US Patent  US8841312 Publication Date 9/23/2014
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Cyclin-dependent kinase 4
Name:CDK4/CDK9
Synonyms:CDK4 | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:Enzyme Subunit
Mol. Mass.:33731.96
Organism:Homo sapiens (Human)
Description:P11802
Residue:303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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  Blast E-value cutoff:
BDBM132440
n/a
NameBDBM132440
Synonyms:US8841312, 186B
TypeSmall organic molecule
Emp. Form.C23H24FN7O
Mol. Mass.433.4814
SMILESO[C@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2c(F)nccc32)nc1 |r|
Structure
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