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TargetCyclin-dependent kinase 6
LigandBDBM132296
Substrate/Competitorn/a
Meas. Tech.In Vitro Assay
pH7.4±n/a
Temperature310.15±n/a K
IC50 3.1±n/a nM
Citation Connors RVKang DEksterowicz JFan PFisher BFu JLi KLi ZMcGee LRSharma RWang XMcMinn DLMihalic JTDeignan J Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors US Patent  US8841312 Publication Date 9/23/2014
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Cyclin-dependent kinase 6
Name:Cyclin-dependent kinase 6
Synonyms:CDK6 | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:Enzyme Subunit
Mol. Mass.:36937.42
Organism:Homo sapiens (Human)
Description:Q00534
Residue:326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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  Blast E-value cutoff:
BDBM132296
n/a
NameBDBM132296
Synonyms:US8841312, 39
TypeSmall organic molecule
Emp. Form.C26H31N7
Mol. Mass.441.5712
SMILESC1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCCCCC2)c2ccccc32)nc1
Structure
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