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TargetCyclin-dependent kinase 6
LigandBDBM50001586
Substrate/Competitorn/a
Meas. Tech.In Vitro Assay
pH7.4±n/a
Temperature310.15±n/a K
IC50 4.3±n/a nM
Citation Connors, RVKang, DEksterowicz, JFan, PFisher, BFu, JLi, KLi, ZMcGee, LRSharma, RWang, XMcMinn, DLMihalic, JTDeignan, J Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors US Patent US8841312 Publication Date 9/23/2014
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Cyclin-dependent kinase 6
Name:Cyclin-dependent kinase 6
Synonyms:CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:Enzyme Subunit
Mol. Mass.:36937.42
Organism:Homo sapiens (Human)
Description:Q00534
Residue:326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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BDBM50001586
n/a
NameBDBM50001586
Synonyms:CHEMBL3237444 | US8841312, 152
TypeSmall organic molecule
Emp. Form.C23H25ClN8
Mol. Mass.448.951
SMILESClc1nccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c12
Structure
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