| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 6 |
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| Ligand | BDBM50001586 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Assay |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 4.3±n/a nM |
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| Citation |  Connors RV; Kang D; Eksterowicz J; Fan P; Fisher B; Fu J; Li K; Li Z; McGee LR; Sharma R; Wang X; McMinn DL; Mihalic JT; Deignan J Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors US Patent US8841312 Publication Date 9/23/2014 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Cyclin-dependent kinase 6 |
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| Name: | Cyclin-dependent kinase 6 |
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| Synonyms: | CDK6 | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 36937.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00534 |
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| Residue: | 326 |
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| Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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| BDBM50001586 |
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| n/a |
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| Name | BDBM50001586 |
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| Synonyms: | CHEMBL3237444 | US8841312, 152 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25ClN8 |
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| Mol. Mass. | 448.951 |
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| SMILES | Clc1nccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c12 |
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| Structure | 
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