| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-5 |
|---|
| Ligand | BDBM10484 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Radioligand Binding Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 277.15±n/a K |
|---|
| Ki | 0.3±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Buettelmann, B; Jakob-Roetne, R; Knust, H; Lucas, MC; Thomas, A Isoxazolo-pyridine derivatives US Patent US8846719 Publication Date 9/30/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Gamma-aminobutyric acid receptor subunit alpha-5 |
|---|
| Name: | Gamma-aminobutyric acid receptor subunit alpha-5 |
|---|
| Synonyms: | GABA receptor alpha-5 subunit | GABA(A) receptor subunit alpha-5 (GABAAa5) | GABRA5 | GBRA5_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A)) | Gamma-aminobutyric acid receptor subunit alpha-5 (GABAA) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52160.59 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P31644 |
|---|
| Residue: | 462 |
|---|
| Sequence: | MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGY
DNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPL
NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDF
PMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTS
TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM
TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA
KIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN
SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
|
|
|
|---|
| BDBM10484 |
|---|
| n/a |
|---|
| Name | BDBM10484 |
|---|
| Synonyms: | US11091471, Example RO-301 | US8846719, 301 |
|---|
| Type | n/a |
|---|
| Emp. Form. | C21H21ClN4O4 |
|---|
| Mol. Mass. | 428.869 |
|---|
| SMILES | Cc1onc(c1COc1ccc(cn1)C(=O)NC1CCOCC1)-c1ccc(Cl)cn1 |
|---|
| Structure | 
|
|---|
Search and Browse
