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TargetCannabinoid receptor 1
LigandBDBM143515
Substrate/Competitorn/a
Meas. Tech.cAMP Assay
Temperature300.15±n/a K
EC50 1.00±n/a nM
Commentsextracted
Citation Macielag MJZhang YDeCorte BLGreco MN Quinazoline derivatives useful as CB-1 inverse agonists US Patent  US9682955 Publication Date 6/20/2017
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM143515
n/a
NameBDBM143515
Synonyms:US9682955, 99
TypeSmall organic molecule
Emp. Form.C33H29Cl2N3O
Mol. Mass.554.509
SMILESOC1(CCC(CC1)Nc1ncnc2ccc(cc12)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1ccccc1 |(6,3.08,;4.67,2.31,;6,1.54,;6,,;4.67,-.77,;3.33,,;3.33,1.54,;4.67,-2.31,;4.67,-3.85,;6,-4.62,;6,-6.16,;4.67,-6.93,;3.33,-6.16,;2,-6.93,;.67,-6.16,;.67,-4.62,;2,-3.85,;3.33,-4.62,;-.67,-3.85,;-2,-4.62,;-3.33,-3.85,;-4.67,-4.62,;-4.67,-6.16,;-6,-6.93,;-3.33,-6.93,;-2,-6.16,;-.67,-2.31,;.67,-1.54,;.67,,;-.67,.77,;-.67,2.31,;-2,,;-2,-1.54,;4.67,3.85,;6,4.62,;6,6.16,;4.67,6.93,;3.33,6.16,;3.33,4.62,)|
Structure
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