Reaction Details |
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] |
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Ligand | BDBM285530 |
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Substrate/Competitor | n/a |
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Meas. Tech. | The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays |
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IC50 | 29.1±n/a nM |
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Citation | Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018 |
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More Info.: | Get all data from this article, Assay Method |
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] |
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Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] |
Synonyms: | DPDE4 | PDE4B | PDE4B1 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 70253.85 |
Organism: | Homo sapiens (Human) |
Description: | Q07343[122-736,S654A] |
Residue: | 615 |
Sequence: | ATFPGHSQRREEFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRN
NFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRS
VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKK
QQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHN
RPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVL
LSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA
VGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSS
GVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEIS
PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQAMIPQAPA
PPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGE
TDIDIATEDKSPVDT
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BDBM285530 |
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n/a |
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Name | BDBM285530 |
Synonyms: | Azetidin-1-yl[3-(3,5-difluoro-4-methoxyphenyl)imidazo[1,2-b]pyridazin-2-yl]methanone (3) | US10077269, Example 3 | US10669279, Example 3 | US9598421, Example 3 |
Type | Small organic molecule |
Emp. Form. | C17H14F2N4O2 |
Mol. Mass. | 344.3155 |
SMILES | COc1c(F)cc(cc1F)-c1c(nc2cccnn12)C(=O)N1CCC1 |
Structure |
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