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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]
LigandBDBM285530
Substrate/Competitorn/a
Meas. Tech.The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays
IC50 29.1±n/a nM
Citation Chappie, TAPatel, NCHayward, MMHelal, CJSciabola, SLaChapelle, EAYoung, JMVerhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018
More Info.:Get all data from this article,  Assay Method
 
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]
Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]
Synonyms:DPDE4 | PDE4B | PDE4B1 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Type:Enzyme Catalytic Domain
Mol. Mass.:70253.85
Organism:Homo sapiens (Human)
Description:Q07343[122-736,S654A]
Residue:615
Sequence:
ATFPGHSQRREEFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRN
NFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRS
VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKK
QQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHN
RPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVL
LSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA
VGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSS
GVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEIS
PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQAMIPQAPA
PPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGE
TDIDIATEDKSPVDT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM285530
n/a
NameBDBM285530
Synonyms:Azetidin-1-yl[3-(3,5-difluoro-4-methoxyphenyl)imidazo[1,2-b]pyridazin-2-yl]methanone (3) | US10077269, Example 3 | US10669279, Example 3 | US9598421, Example 3
TypeSmall organic molecule
Emp. Form.C17H14F2N4O2
Mol. Mass.344.3155
SMILESCOc1c(F)cc(cc1F)-c1c(nc2cccnn12)C(=O)N1CCC1
Structure
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