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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D
LigandBDBM285547
Substrate/Competitorn/a
Meas. Tech.The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays
IC50 490±n/a nM
Citation Chappie TAPatel NCHayward MMHelal CJSciabola SLaChapelle EAYoung JMVerhoest PR Imidazopyridazine compounds US Patent  US10077269 Publication Date 9/18/2018
More Info.:Get all data from this article,  Assay Method
 
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Name:Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Synonyms:NP_000914.2 | PDE4C1 | PDE4D3 | PDE4E3 | Q08499-2
Type:n/a
Mol. Mass.:76431.39
Organism:Homo sapiens (Human)
Description:Q08499-2
Residue:673
Sequence:
MMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSD
SDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSP
MCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNREL
THLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSL
TNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKT
FKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAI
FASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTK
KQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMV
HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID
YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQF
ELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQ
PEACVIDDRSPDT
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  Blast E-value cutoff:
BDBM285547
n/a
NameBDBM285547
Synonyms:4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazin-3-yl]-2-fluoro-5-methylbenzonitrile | US10077269, Example 20 | US9598421, Example 20
TypeSmall organic molecule
Emp. Form.C18H14FN5O
Mol. Mass.335.3351
SMILESCc1cc(C#N)c(F)cc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-8.25,-24.93,;-6.77,-24.54,;-6.37,-23.05,;-4.88,-22.65,;-4.48,-21.16,;-4.16,-19.66,;-3.79,-23.74,;-2.3,-23.34,;-4.19,-25.23,;-5.68,-25.62,;-6.08,-27.11,;-5.17,-28.36,;-6.08,-29.6,;-7.54,-29.13,;-8.87,-29.9,;-10.21,-29.13,;-10.21,-27.59,;-8.87,-26.82,;-7.54,-27.59,;-3.63,-28.36,;-2.86,-27.02,;-2.86,-29.69,;-3.26,-31.18,;-1.77,-31.58,;-1.37,-30.09,)|
Structure
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