| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) |
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| Ligand | BDBM285568 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays |
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| IC50 | 467±n/a nM |
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| Citation |  Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) |
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| Name: | Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) |
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| Synonyms: | DPDE3 | Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D | NP_000914.2 | PDE4C1 | PDE4D | PDE4D3 | PDE4D_HUMAN | PDE4E3 | Q08499-2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) |
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| Type: | n/a |
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| Mol. Mass.: | 76431.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08499-2 |
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| Residue: | 673 |
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| Sequence: | MMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSD
SDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSP
MCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNREL
THLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSL
TNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKT
FKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAI
FASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTK
KQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMV
HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID
YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQF
ELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQ
PEACVIDDRSPDT
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| BDBM285568 |
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| n/a |
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| Name | BDBM285568 |
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| Synonyms: | N-cyclopropyl-3-(3-fluoro-4-methylphenyl)imidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 41 | US10669279, Example 41 | US9598421, Example 41 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15FN4O |
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| Mol. Mass. | 310.3256 |
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| SMILES | Cc1ccc(cc1F)-c1c(nc2cccnn12)C(=O)NC1CC1 |
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| Structure | 
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