Ki Summary

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Target

cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]

Ligand

BDBM285574

Substrate/Competitor

n/a

Meas. Tech.

The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays

IC50

3.90±n/a nM

Citation

Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018

More Info.:

Get all data from this article, Assay Method

cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]

Name:

cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A]

Synonyms:

DPDE4 | PDE4B | PDE4B1 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Type:

Enzyme Catalytic Domain

Mol. Mass.:

70253.85

Organism:

Homo sapiens (Human)

Description:

Q07343[122-736,S654A]

Residue:

615

Sequence:

ATFPGHSQRREEFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRN
NFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRS
VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKK
QQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHN
RPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVL
LSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA
VGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSS
GVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEIS
PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQAMIPQAPA
PPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGE
TDIDIATEDKSPVDT

BDBM285574

n/a

Name

BDBM285574

Synonyms:

US10077269, Example 47 | US10669279, Example 47 | US9598421, Example 47 | azetidin-1-yl[3-(4-chloro-3,5-difluorophenyl)imidazo[1,2-b]pyridazin-2-yl]methanone

Type

Small organic molecule

Emp. Form.

C16H11ClF2N4O

Mol. Mass.

348.735

SMILES

Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1

Structure