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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | ||
| Ligand | BDBM285579 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays | ||
| IC50 | 24.3±n/a nM | ||
| Citation |  Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | |||
| Name: | Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | ||
| Synonyms: | DPDE2 | PDE4A | PDE4A1 | PDE4A_HUMAN | Phosphodiesterase 4A (PDE4A1) | Phosphodiesterase 4A1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | cAMP-specific 3',5'-cyclic phosphodiesterase 4A Isoform 4 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 72186.86 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P27815-4 | ||
| Residue: | 647 | ||
| Sequence: |
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| BDBM285579 | |||
| n/a | |||
| Name | BDBM285579 | ||
| Synonyms: | US10077269, Example 52 | US10669279, Example 52 | US9598421, Example 52 | azetidin-1-yl[3-(4-chloro-2-fluorophenyl)imidazo[1,2-b]pyridazin-2-yl]methanone | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H12ClFN4O | ||
| Mol. Mass. | 330.744 | ||
| SMILES | Fc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-2.46,1.44,;-.98,1.83,;-.58,3.32,;.91,3.72,;1.31,5.21,;2,2.63,;1.6,1.14,;.11,.75,;-.29,-.74,;.62,-1.99,;-.29,-3.23,;-1.75,-2.76,;-3.08,-3.53,;-4.42,-2.76,;-4.42,-1.22,;-3.08,-.45,;-1.75,-1.22,;2.16,-1.99,;2.93,-.65,;2.93,-3.32,;2.53,-4.81,;4.02,-5.21,;4.42,-3.72,)| | ||
| Structure | 
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