Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] | ||
Ligand | BDBM285595 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays | ||
IC50 | 35.4±n/a nM | ||
Citation | Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] | ||
Synonyms: | DPDE4 | PDE4B | PDE4B1 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 70253.85 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343[122-736,S654A] | ||
Residue: | 615 | ||
Sequence: |
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BDBM285595 | |||
n/a | |||
Name | BDBM285595 | ||
Synonyms: | 3-(4-chloro-2-fluorophenyl)-N-[(1R,2S)-2-fluorocyclopro-pyl]imidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 68 | US10669279, Example 68 | US9598421, Example 68 | ||
Type | Small organic molecule | ||
Emp. Form. | C16H11ClF2N4O | ||
Mol. Mass. | 348.735 | ||
SMILES | F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)cc1F |r,wU:3.4,1.0,(5.5,-1.78,;4.73,-3.11,;4.73,-4.65,;3.39,-3.88,;1.85,-3.88,;1.08,-2.55,;1.85,-1.21,;-.46,-2.55,;-1.36,-3.79,;-2.83,-3.32,;-4.16,-4.09,;-5.5,-3.32,;-5.5,-1.78,;-4.16,-1.01,;-2.83,-1.78,;-1.36,-1.3,;-.96,.19,;.52,.59,;.92,2.07,;-.17,3.16,;.23,4.65,;-1.66,2.76,;-2.05,1.28,;-3.54,.88,)| | ||
Structure |