Ki Summary

Reaction Details

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Target

cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1

Ligand

BDBM285598

Substrate/Competitor

n/a

Meas. Tech.

The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays

IC50

2.00±n/a nM

Citation

Chappie TA; Patel NC; Hayward MM; Helal CJ; Sciabola S; LaChapelle EA; Young JM; Verhoest PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018

More Info.:

Get all data from this article, Assay Method

cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1

Name:

Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D

Synonyms:

NP_000914.2 | PDE4C1 | PDE4D3 | PDE4E3 | Q08499-2

Type:

n/a

Mol. Mass.:

76431.39

Organism:

Homo sapiens (Human)

Description:

Q08499-2

Residue:

673

Sequence:

MMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSD
SDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSP
MCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNREL
THLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSL
TNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKT
FKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAI
FASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTK
KQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMV
HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFID
YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQF
ELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQ
PEACVIDDRSPDT

BDBM285598

n/a

Name

BDBM285598

Synonyms:

3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyclopro-pyl]imidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 71 | US9598421, Example 71

Type

Small organic molecule

Emp. Form.

C17H14ClFN4O

Mol. Mass.

344.771

SMILES

Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r|

Structure