Reaction Details |
| Report a problem with these data |
Target | Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) |
---|
Ligand | BDBM285602 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays |
---|
IC50 | 10.5±n/a nM |
---|
Citation | Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) |
---|
Name: | Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) |
Synonyms: | DPDE2 | PDE4A | PDE4A1 | PDE4A_HUMAN | Phosphodiesterase 4A (PDE4A1) | Phosphodiesterase 4A1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | cAMP-specific 3',5'-cyclic phosphodiesterase 4A Isoform 4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 72186.86 |
Organism: | Homo sapiens (Human) |
Description: | P27815-4 |
Residue: | 647 |
Sequence: | MPLVDFFCETCSKPWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE
IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKT
DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM
LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG
VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVID
MVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL
ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD
LVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE
EISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYL
TQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGL
PSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
|
|
|
BDBM285602 |
---|
n/a |
---|
Name | BDBM285602 |
Synonyms: | N-cyclopropyl-3-[2-(difluoro-methoxy)pyridin-4-yl]imidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 75 | US10669279, Example 75 | US9598421, Example 75 |
Type | Small organic molecule |
Emp. Form. | C16H13F2N5O2 |
Mol. Mass. | 345.3035 |
SMILES | FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)NC1CC1 |
Structure |
|