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TargetIsoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1)
LigandBDBM285602
Substrate/Competitorn/a
Meas. Tech.The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays
IC50 10.5±n/a nM
Citation Chappie, TAPatel, NCHayward, MMHelal, CJSciabola, SLaChapelle, EAYoung, JMVerhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018
More Info.:Get all data from this article,  Assay Method
 
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1)
Name:Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1)
Synonyms:DPDE2 | PDE4A | PDE4A1 | PDE4A_HUMAN | Phosphodiesterase 4A (PDE4A1) | Phosphodiesterase 4A1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | cAMP-specific 3',5'-cyclic phosphodiesterase 4A Isoform 4
Type:Enzyme Catalytic Domain
Mol. Mass.:72186.86
Organism:Homo sapiens (Human)
Description:P27815-4
Residue:647
Sequence:
MPLVDFFCETCSKPWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE
IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKT
DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM
LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG
VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVID
MVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL
ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD
LVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE
EISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYL
TQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGL
PSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM285602
n/a
NameBDBM285602
Synonyms:N-cyclopropyl-3-[2-(difluoro-methoxy)pyridin-4-yl]imidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 75 | US10669279, Example 75 | US9598421, Example 75
TypeSmall organic molecule
Emp. Form.C16H13F2N5O2
Mol. Mass.345.3035
SMILESFC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)NC1CC1
Structure
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