| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] |
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| Ligand | BDBM285616 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays |
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| IC50 | 7.72±n/a nM |
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| Citation |  Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] |
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| Synonyms: | DPDE4 | PDE4B | PDE4B1 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 70253.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07343[122-736,S654A] |
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| Residue: | 615 |
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| Sequence: | ATFPGHSQRREEFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRN
NFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRS
VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKK
QQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHN
RPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVL
LSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA
VGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSS
GVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEIS
PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQAMIPQAPA
PPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGE
TDIDIATEDKSPVDT
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| BDBM285616 |
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| n/a |
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| Name | BDBM285616 |
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| Synonyms: | US10077269, Example 86 | US10669279, Example 86 | US9598421, Example 86 | azetidin-1-yl[3-(2,2-difluoro-1,3-benzodioxol-5-yl)imidazo[1,2-b]pyridazin-2-yl]methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12F2N4O3 |
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| Mol. Mass. | 358.299 |
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| SMILES | FC1(F)Oc2ccc(cc2O1)-c1c(nc2cccnn12)C(=O)N1CCC1 |
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| Structure | 
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