Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | ||
| Ligand | BDBM285622 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays | ||
| IC50 | 5.52±n/a nM | ||
| Citation |  Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10077269 Publication Date 9/18/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | |||
| Name: | Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | ||
| Synonyms: | DPDE2 | PDE4A | PDE4A1 | PDE4A_HUMAN | Phosphodiesterase 4A (PDE4A1) | Phosphodiesterase 4A1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) | cAMP-specific 3',5'-cyclic phosphodiesterase 4A Isoform 4 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 72186.86 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P27815-4 | ||
| Residue: | 647 | ||
| Sequence: |
| ||
| BDBM285622 | |||
| n/a | |||
| Name | BDBM285622 | ||
| Synonyms: | 3-(4-cyano-2,5-difluorophenyl)-N-cyclopropylimidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 92 | US10669279, Example 92 | US9598421, Example 92 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H11F2N5O | ||
| Mol. Mass. | 339.2989 | ||
| SMILES | Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1C#N |(2.79,1.73,;1.31,1.33,;.91,-.16,;-.58,-.56,;-.98,-2.04,;-.07,-3.29,;-.98,-4.54,;-2.44,-4.06,;-3.78,-4.83,;-5.11,-4.06,;-5.11,-2.52,;-3.78,-1.75,;-2.44,-2.52,;1.47,-3.29,;2.24,-1.96,;2.24,-4.62,;3.78,-4.62,;5.11,-5.39,;5.11,-3.85,;-1.67,.53,;-3.16,.13,;-1.27,2.02,;.21,2.51,;.59,4.01,;.97,5.5,)| | ||
| Structure | 
| ||