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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
LigandBDBM285629
Substrate/Competitorn/a
Meas. Tech.The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays
IC50 19.8±n/a nM
Citation Chappie TAPatel NCHayward MMHelal CJSciabola SLaChapelle EAYoung JMVerhoest PR Imidazopyridazine compounds US Patent  US10077269 Publication Date 9/18/2018
More Info.:Get all data from this article,  Assay Method
 
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
Synonyms:NP_001104779 | PDE4A
Type:Enzyme Catalytic Domain
Mol. Mass.:91000.95
Organism:Homo sapiens (Human)
Description:n/a
Residue:823
Sequence:
SGAAPRARPRPPALALPPTGPESLTHFPFSDEDTRRHPPGRSVSFEAENGPTPSPGRSPL
DSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQ
VLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLE
QLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSP
TMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEE
LLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLE
DHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQ
FLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLA
TDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYR
QWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHP
DAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISM
AQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQA
QSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTA
AEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM285629
n/a
NameBDBM285629
Synonyms:3-(4-cyano-5-fluoro-2-methylphenyl)-N-(propan-2-yl)imidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 99 | US9598421, Example 99
TypeSmall organic molecule
Emp. Form.C18H16FN5O
Mol. Mass.337.3509
SMILESCC(C)NC(=O)c1nc2cccnn2c1-c1cc(F)c(cc1C)C#N |(4.83,-5.68,;4.06,-4.34,;4.83,-3.01,;2.52,-4.34,;1.75,-3.01,;2.52,-1.67,;.21,-3.01,;-.7,-4.25,;-2.16,-3.78,;-3.49,-4.55,;-4.83,-3.78,;-4.83,-2.24,;-3.49,-1.47,;-2.16,-2.24,;-.7,-1.76,;-.3,-.27,;1.19,.12,;1.59,1.61,;3.08,2.01,;.49,2.8,;-.99,2.3,;-1.39,.81,;-2.87,.42,;.87,4.29,;1.25,5.78,)|
Structure
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