Reaction Details |
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Target | C5a anaphylatoxin chemotactic receptor 1 |
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Ligand | BDBM134546 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLIPR Assay |
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IC50 | 2±n/a nM |
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Citation | Adams, CM; Darsigny, V; Flyer, AN; Gelin, CF; Hurley, TB; Ji, N; Karki, RG; Kawanami, T; Meredith, E; Rao, C; Serrano-Wu, MH; Solovay, CF Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators US Patent US8846656 Publication Date 9/30/2014 |
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More Info.: | Get all data from this article, Assay Method |
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C5a anaphylatoxin chemotactic receptor 1 |
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Name: | C5a anaphylatoxin chemotactic receptor 1 |
Synonyms: | C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88 |
Type: | Enzyme |
Mol. Mass.: | 39347.68 |
Organism: | Homo sapiens (Human) |
Description: | P21730 |
Residue: | 350 |
Sequence: | MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
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BDBM134546 |
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n/a |
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Name | BDBM134546 |
Synonyms: | US8846656, 29 |
Type | Small organic molecule |
Emp. Form. | C32H40N6O2S |
Mol. Mass. | 572.764 |
SMILES | CC(C)c1ccc(C)c(c1)N1CCc2nc(nc(N3CCN([C@H](C)C3)S(C)(=O)=O)c2C1)-c1cccc2[nH]cc(C)c12 |r| |
Structure |
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