| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50293077 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| Temperature | 298.15±n/a K |
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| Kd | 25±n/a nM |
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| Comments | extracted |
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| Citation |  Clinch, K; Evans, GB; Furneaux, RH; Gulab, SA; Kelly, PM; Schramm, VL; Tyler, PC; Woolhouse, AD Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases US Patent US8853224 Publication Date 10/7/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50293077 |
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| n/a |
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| Name | BDBM50293077 |
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| Synonyms: | 7-{[(4-Hydroxybutyl)amino]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL449072 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H16N4O2 |
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| Mol. Mass. | 236.2703 |
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| SMILES | OCCCCNCc1c[nH]c2c1nc[nH]c2=O |
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| Structure | 
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