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TargetProstaglandin D Synthase
LigandBDBM136525
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH8±n/a
Temperature298.15±n/a K
IC50 37±n/a nM
Commentsextracted
Citation Urade YKitade MShigeno KYamane KTanaka K Piperazine compound capable of inhibiting prostaglandin D synthase US Patent  US8865714 Publication Date 10/21/2014
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D Synthase
Name:Prostaglandin D Synthase
Synonyms:Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | Prostaglandin D
Type:Enzyme
Mol. Mass.:23341.07
Organism:Homo sapiens (Human)
Description:The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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  Blast E-value cutoff:
BDBM136525
n/a
NameBDBM136525
Synonyms:US8865714, 12
TypeSmall organic molecule
Emp. Form.C27H36N8O2
Mol. Mass.504.6271
SMILESCn1cccc1C(=O)N1CCN(CC1)C(=O)Nc1ccc(cc1)N1CCC(CCCn2ccnn2)CC1
Structure
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