| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM136702 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescent Activity Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 4.4±0.45 nM |
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| Comments | extracted |
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| Citation |  Ganesan, A; Packham, GK; Cecil, AR Depsipeptides and their therapeutic use US Patent US8865655 Publication Date 10/21/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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|
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| BDBM136702 |
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| n/a |
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| Name | BDBM136702 |
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| Synonyms: | US8865655, 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H37N3O6S |
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| Mol. Mass. | 471.611 |
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| SMILES | CC(C)[C@H]1NC(=O)[C@@H](C)NC(=O)[C@H](NC(=O)C[C@H](OC(=O)C[C@@H]1O)\C=C\CCS)C(C)C |r| |
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| Structure | 
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