| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM285765 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | RORgammat (full-length human) Reporter Assay A |
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| IC50 | 7.00±n/a nM |
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| Citation |  Goldberg, S; Steeneck, C; Gege, C; Kinzel, O; Kleymann, G; Hoffmann, T; Fourie, AM; Xue, X Thiazoles as modulators of RORγt US Patent US10080744 Publication Date 9/25/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM285765 |
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| n/a |
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| Name | BDBM285765 |
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| Synonyms: | US10080744, Example 3/32 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H25F7N4O5S2 |
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| Mol. Mass. | 694.641 |
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| SMILES | CC[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2Cc2ccc(F)cc2)-c2nnc(CC(C)(C)C(O)=O)o2)c(C(F)F)c1F)C(F)(F)F |r| |
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| Structure | 
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