| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase alpha-1 |
|---|
| Ligand | BDBM139540 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Inhibition Assay |
|---|
| IC50 | 0.19±n/a nM |
|---|
| Citation |  Reddy, EP; Reddy, MV Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof US Patent US8889696 Publication Date 11/18/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ribosomal protein S6 kinase alpha-1 |
|---|
| Name: | Ribosomal protein S6 kinase alpha-1 |
|---|
| Synonyms: | 90 kDa ribosomal protein S6 kinase 1 | KS6A1_HUMAN | MAP kinase-activated protein kinase 1a | MAPKAPK1A | RPS6KA1 | RPS6KA1(Kin.Dom.1 - N-terminal) | RPS6KA1(Kin.Dom.2 - C-terminal) | RSK-1 | RSK1 | Ribosomal S6 Kinase 1 (RSK-1) | Ribosomal S6 kinase 1 | Ribosomal S6 kinase 1 (RSK1) | Ribosomal protein S6 kinase alpha 1 | Ribosomal protein S6 kinase alpha-1 | Ribosomal protein S6 kinase alpha-1 (RSK1) | S6K-alpha 1 | p90-RSK 1 | p90RSK | p90S6K | pp90RSK1 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 82736.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 735 |
|---|
| Sequence: | MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPS
HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVN
HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS
LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHS
HSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRN
PANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTP
KDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVV
KETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYD
DGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSN
ILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSL
GILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP
HQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESS
ILAQRRVRKLPSTTL
|
|
|
|---|
| BDBM139540 |
|---|
| n/a |
|---|
| Name | BDBM139540 |
|---|
| Synonyms: | US10189849, staurosporine | US10307427, Staurosporine | US10329300, Staurosporine | US11091485, Compound Staurosporine | US11542261, Compound staurosporine | US11814388, Compound Staurosporine | US20230312583, Compound staurosporine | US20240025908, Example Staurosporine | US8889696, Staurosporine | US9051313, Staurosporine | US9586965, Control Staurosporine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H24N4O3 |
|---|
| Mol. Mass. | 452.5045 |
|---|
| SMILES | CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
