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TargetP70S6K (T412E)
LigandBDBM224460
Substrate/Competitorn/a
Meas. Tech.P70S6K Enzyme Assay
pH7.5±n/a
IC50 2.50±n/a nM
Commentsextracted
Citation Lan RHuck BRChen XDeselm LCQiu HXiao YNeagu CMochalkin IJohnson TL Aminopyrimidine derivatives for use as modulators of kinase activity US Patent  US10080750 Publication Date 9/25/2018
More Info.:Get all data from this article,  Assay Method
 
P70S6K (T412E)
Name:P70S6K (T412E)
Synonyms:p70 ribosomal S6 kinase alpha (P70S6K)(T412E)
Type:Enzyme Catalytic Domain
Mol. Mass.:59166.89
Organism:Homo sapiens (Human)
Description:n/a
Residue:525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM224460
n/a
NameBDBM224460
Synonyms:US10080750, Compound 138 | US9321760, 138 | US9662330, Compound 138
TypeSmall organic molecule
Emp. Form.C22H22ClFN4O
Mol. Mass.412.888
SMILESNc1ncnc(N2CCC(CC2)C(O)c2ccc(Cl)cc2)c1-c1ccc(F)cc1
Structure
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