| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 3 |
|---|
| Ligand | BDBM139909 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Kinase Inhibitory Activity Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 0.78±n/a nM |
|---|
| Citation |  Berdini, V; Besong, GE; Callaghan, O; Carr, MG; Congreve, MS; Gill, AL; Griffiths-Jones, CM; Madin, A; Murray, CW; Nijjar, RK; O'Brien, MA; Pike, A; Saxty, G; Taylor, RD; Vickerstaffe, E Bicyclic heterocyclic compounds as FGFR inhibitors US Patent US8895745 Publication Date 11/25/2014 |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Fibroblast growth factor receptor 3 |
|---|
| Name: | Fibroblast growth factor receptor 3 |
|---|
| Synonyms: | CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 87699.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22607 |
|---|
| Residue: | 806 |
|---|
| Sequence: | MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE
EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK
RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE
GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN
LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ
VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW
MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT
HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS
SSSGDDSVFAHDLLPPAPPSSGGSRT
|
|
|
|---|
| BDBM139909 |
|---|
| n/a |
|---|
| Name | BDBM139909 |
|---|
| Synonyms: | US8895745, 310 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H15F3N6OS |
|---|
| Mol. Mass. | 432.422 |
|---|
| SMILES | Cc1nnc(s1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
