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TargetN-acetyl-beta-D-glucosaminidase (O-GlcNAcase)
LigandBDBM139952
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH7±n/a
Temperature298.15±n/a K
Ki 0.17±n/a nM
Commentsextracted
Citation Chang JLiu KMcEachern EJMu CSelnick HGShi FVocadlo DJWang YWei ZZhou YZhu Y Selective glycosidase inhibitors and uses thereof US Patent  US8901087 Publication Date 12/2/2014
More Info.:Get all data from this article,  Assay Method
 
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)
Name:N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)
Synonyms:2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | Beta-N-acetylhexosaminidase | Beta-hexosaminidase (O-GlcNAcase) | Bifunctional protein NCOAT | O-glycoprotein 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | Protein O-GlcNAcase
Type:Enzyme
Mol. Mass.:102874.67
Organism:Homo sapiens (Human)
Description:O60502
Residue:916
Sequence:
MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRF
LCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLM
TLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNM
CAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEK
LLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRS
TELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLE
NEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAA
PSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKND
NQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVP
GPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKD
SEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQW
LGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPY
FPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYA
LGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFP
SLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIA
KMEGFPKDVVILGRSL
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  Blast E-value cutoff:
BDBM139952
n/a
NameBDBM139952
Synonyms:US8901087, 97
TypeSmall organic molecule
Emp. Form.C11H17F3N2O4S
Mol. Mass.330.324
SMILESCCCNC1=N[C@H]2[C@H](O[C@H]([C@@H](O)C(F)(F)F)[C@@H](O)[C@@H]2O)S1 |t:4|
Structure
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