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TargetPhosphodiesterase
LigandBDBM140069
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH6.5±n/a
Temperature277.15±n/a K
IC50 1500±n/a nM
Commentsextracted
Citation Inoue, HMurafuji, HHayashi, Y Thienopyrazole derivative having PDE7 inhibitory activity US Patent US8901315 Publication Date 12/2/2014
More Info.:Get all data from this article,  Assay Method
 
Phosphodiesterase
Name:Phosphodiesterase
Synonyms:Phosphodiesterase 4 (PDE4)
Type:Protein
Mol. Mass.:82059.36
Organism:Mus musculus (Mouse)
Description:Q8VBU5
Residue:721
Sequence:
MTAKNSPKEFTASESEVCIKTFKEQMRLELELPKLPGNRPTSPKISPRSSPRNSPCFFRK
LLVNKSIRQRRRFTVAHTCFDVENGPSPGRSPLDPQAGSSSGLVLHAAFPGHSQRRESFL
YRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTLLTNLHGAPNK
RSPAASQAPVSRVSLQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLN
RELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLM
HSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQER
DLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLE
ILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIF
QNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQV
LRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQ
VGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQGLM
EKFQFELTLEEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLEETDIDIATEDKSPID
T
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  Blast E-value cutoff:
BDBM140069
n/a
NameBDBM140069
Synonyms:US8901315, 114 | US8901315, 367 | US8901315, 368
TypeSmall organic molecule
Emp. Form.C24H30N4O2S
Mol. Mass.438.586
SMILESCc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(cc1)N1CCC(O)CC1
Structure
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