Ki Summary

Reaction Details

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Target

Phosphodiesterase

Ligand

BDBM140094

Substrate/Competitor

n/a

Meas. Tech.

Inhibition Assay

6.5±n/a

Temperature

277.15±n/a K

IC50

1600±n/a nM

Comments

extracted

Citation

Inoue, H; Murafuji, H; Hayashi, Y Thienopyrazole derivative having PDE7 inhibitory activity US Patent US8901315 Publication Date 12/2/2014

More Info.:

Get all data from this article, Assay Method

Phosphodiesterase

Name:

Phosphodiesterase

Synonyms:

Phosphodiesterase 4 (PDE4)

Type:

Protein

Mol. Mass.:

82059.36

Organism:

Mus musculus (Mouse)

Description:

Q8VBU5

Residue:

721

Sequence:

MTAKNSPKEFTASESEVCIKTFKEQMRLELELPKLPGNRPTSPKISPRSSPRNSPCFFRK
LLVNKSIRQRRRFTVAHTCFDVENGPSPGRSPLDPQAGSSSGLVLHAAFPGHSQRRESFL
YRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTLLTNLHGAPNK
RSPAASQAPVSRVSLQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLN
RELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLM
HSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQER
DLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLE
ILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIF
QNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQV
LRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQ
VGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQGLM
EKFQFELTLEEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLEETDIDIATEDKSPID
T

BDBM140094

n/a

Name

BDBM140094

Synonyms:

US8901315, 177

Type

Small organic molecule

Emp. Form.

C25H38N4O2S

Mol. Mass.

458.66

SMILES

C[C@H]1CN(C[C@@H](C)O1)[C@H]1CC[C@@H](CC1)NC(=O)c1cc2c(C)nn(C3CCCCC3)c2s1 |r,wU:11.15,5.5,1.0,wD:8.8,(8.83,-.48,;8.06,.85,;6.52,.85,;5.75,2.19,;6.52,3.52,;8.06,3.52,;8.83,4.85,;8.83,2.19,;4.21,2.19,;3.44,3.52,;1.9,3.52,;1.13,2.19,;1.9,.85,;3.44,.85,;-.41,2.19,;-1.18,.85,;-.41,-.48,;-2.72,.85,;-3.62,2.1,;-5.09,1.62,;-6.55,2.1,;-7.32,3.43,;-7.46,.85,;-6.55,-.39,;-6.95,-1.88,;-8.44,-2.28,;-8.83,-3.77,;-7.75,-4.85,;-6.26,-4.46,;-5.86,-2.97,;-5.09,.08,;-3.62,-.39,)|

Structure