Ki Summary

Reaction Details

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Target

Phosphodiesterase

Ligand

BDBM140177

Substrate/Competitor

n/a

Meas. Tech.

Inhibition Assay

6.5±n/a

Temperature

277.15±n/a K

IC50

900±n/a nM

Comments

extracted

Citation

Inoue, H; Murafuji, H; Hayashi, Y Thienopyrazole derivative having PDE7 inhibitory activity US Patent US8901315 Publication Date 12/2/2014

More Info.:

Get all data from this article, Assay Method

Phosphodiesterase

Name:

Phosphodiesterase

Synonyms:

Phosphodiesterase 4 (PDE4)

Type:

Protein

Mol. Mass.:

82059.36

Organism:

Mus musculus (Mouse)

Description:

Q8VBU5

Residue:

721

Sequence:

MTAKNSPKEFTASESEVCIKTFKEQMRLELELPKLPGNRPTSPKISPRSSPRNSPCFFRK
LLVNKSIRQRRRFTVAHTCFDVENGPSPGRSPLDPQAGSSSGLVLHAAFPGHSQRRESFL
YRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTLLTNLHGAPNK
RSPAASQAPVSRVSLQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLN
RELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLM
HSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQER
DLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLE
ILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIF
QNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQV
LRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQ
VGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQGLM
EKFQFELTLEEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLEETDIDIATEDKSPID
T

BDBM140177

n/a

Name

BDBM140177

Synonyms:

US8901315, 396

Type

Small organic molecule

Emp. Form.

C23H35N5O4S2

Mol. Mass.

509.685

SMILES

Cc1nn(C2CCOCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCN(CC1)S(C)(=O)=O |r,wU:18.20,wD:21.27,(-8.76,4.1,;-7.99,2.77,;-8.89,1.52,;-7.99,.27,;-8.39,-1.21,;-9.87,-1.61,;-10.27,-3.1,;-9.18,-4.19,;-7.69,-3.79,;-7.3,-2.3,;-6.52,.75,;-5.06,.27,;-4.15,1.52,;-5.06,2.77,;-6.52,2.29,;-2.61,1.52,;-1.84,.19,;-1.84,2.85,;-.3,2.85,;.47,4.19,;2.01,4.19,;2.78,2.85,;2.01,1.52,;.47,1.52,;4.32,2.85,;5.09,4.19,;6.63,4.19,;7.4,2.85,;6.63,1.52,;5.09,1.52,;8.94,2.85,;9.71,4.19,;8.17,1.52,;10.27,2.08,)|

Structure