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TargetPhosphodiesterase
LigandBDBM140184
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH6.5±n/a
Temperature277.15±n/a K
IC50 1300±n/a nM
Commentsextracted
Citation Inoue, HMurafuji, HHayashi, Y Thienopyrazole derivative having PDE7 inhibitory activity US Patent US8901315 Publication Date 12/2/2014
More Info.:Get all data from this article,  Assay Method
 
Phosphodiesterase
Name:Phosphodiesterase
Synonyms:Phosphodiesterase 4 (PDE4)
Type:Protein
Mol. Mass.:82059.36
Organism:Mus musculus (Mouse)
Description:Q8VBU5
Residue:721
Sequence:
MTAKNSPKEFTASESEVCIKTFKEQMRLELELPKLPGNRPTSPKISPRSSPRNSPCFFRK
LLVNKSIRQRRRFTVAHTCFDVENGPSPGRSPLDPQAGSSSGLVLHAAFPGHSQRRESFL
YRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTLLTNLHGAPNK
RSPAASQAPVSRVSLQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLN
RELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLM
HSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQER
DLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLE
ILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIF
QNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQV
LRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQ
VGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQGLM
EKFQFELTLEEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLEETDIDIATEDKSPID
T
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  Blast E-value cutoff:
BDBM140184
n/a
NameBDBM140184
Synonyms:US8901315, 416
TypeSmall organic molecule
Emp. Form.C24H35N5O2S
Mol. Mass.457.632
SMILESCN1CCN([C@H]2CC[C@@H](CC2)NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)C(=O)C1 |r,wU:8.11,wD:5.4,(9.6,2.19,;8.06,2.19,;7.29,.85,;5.75,.85,;4.98,2.19,;3.44,2.19,;2.67,3.52,;1.13,3.52,;.36,2.19,;1.13,.85,;2.67,.85,;-1.18,2.19,;-1.95,.85,;-1.18,-.48,;-3.49,.85,;-4.39,2.1,;-5.86,1.62,;-7.32,2.1,;-8.09,3.43,;-8.23,.85,;-7.32,-.39,;-7.72,-1.88,;-9.21,-2.28,;-9.6,-3.77,;-8.52,-4.85,;-7.03,-4.46,;-6.63,-2.97,;-5.86,.08,;-4.39,-.39,;5.75,3.52,;4.98,4.85,;7.29,3.52,)|
Structure
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